Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.

نویسندگان

  • Hiroshi Kakeya
  • Yoshitsugu Miyazaki
  • Hisato Senda
  • Tsutomu Kobayashi
  • Masafumi Seki
  • Koichi Izumikawa
  • Yoshihiro Yamamoto
  • Kazunori Yanagihara
  • Takayoshi Tashiro
  • Shigeru Kohno
چکیده

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

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منابع مشابه

Efficacy of SPK-843, a Novel Polyene Antifungal in a Murine Model of Systemic Cryptococcosis Running title: EFFICACY OF SPK-843 IN MURINE CRYPTOCOCCOSIS MODEL

Title Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis Author(s) Hiroshi, Kakeya; Miyazaki, Yoshitsugu; Senda, Hisato; Kobayashi, Tsutomu; Seki, Masafumi; Izumikawa, Koichi; Yamamoto, Yoshihiro; Yanagihara, Kazunori; Tashiro, Takayoshi; Kohno, Shigeru Citation Antimicrobial Agents and Chemotherapy, 52(5), p.1871-1872; 2008 Issue Date 2008-05 URL http...

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SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 52 5  شماره 

صفحات  -

تاریخ انتشار 2008