Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.
نویسندگان
چکیده
SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.
منابع مشابه
Efficacy of SPK-843, a Novel Polyene Antifungal in a Murine Model of Systemic Cryptococcosis Running title: EFFICACY OF SPK-843 IN MURINE CRYPTOCOCCOSIS MODEL
Title Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis Author(s) Hiroshi, Kakeya; Miyazaki, Yoshitsugu; Senda, Hisato; Kobayashi, Tsutomu; Seki, Masafumi; Izumikawa, Koichi; Yamamoto, Yoshihiro; Yanagihara, Kazunori; Tashiro, Takayoshi; Kohno, Shigeru Citation Antimicrobial Agents and Chemotherapy, 52(5), p.1871-1872; 2008 Issue Date 2008-05 URL http...
متن کاملEfficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis.
SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).
متن کاملPotent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.
A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.
متن کاملEnhancement of antifungal chemotherapy by interferon-gamma in experimental systemic cryptococcosis.
The possible enhancement, using immunotherapy with interferon-gamma (IFN-gamma), combined with conventional antifungal therapy, was studied in a murine model of systemic cryptococcosis. Four weeks after intravenous challenge, infection was quantified in brains and livers of survivors. Groups received IFN-gamma every other day beginning 7 days before (prophylaxis), or after infection (14 doses),...
متن کاملAntifungal agents: Polyene, azole, antimetabolite, other and future agents
Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality. This study is desig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 5 شماره
صفحات -
تاریخ انتشار 2008